Foot-and-mouth And Similar Transboundary (FAST) animal diseases pose a substantial threat to disease-free countries, where single incursions can have devastating outcomes, while controlling them in endemic areas can generate positive effects for national economies, livelihoods of livestock keepers, and animal welfare. Surveillance and control programs are often expensive and logistically challenging: in this context, developing integrated programs targeting FAST diseases with similar characteristics might improve use of resources, capacities and accelerate the achievement of animal health targets. The OS22 will explore challenges and opportunities offered by digital transformation, innovation, and partnerships in the fight against FAST diseases.