Globally we are a pivotal moment in the changing epidemiology of avian influenza. Many countries have been responding to unprecedented challenges caused by the HPAI panzootic over the past 2 years, with mortality events in wildlife causing significant conservation concerns, massive socioeconomic impacts on the poultry industry, and outbreaks is novel hosts and reservoirs. Concerningly, we are facing the potential of increased mammalian spread following mortality events in marine mammals and continued transmissions in the dairy industry. This highlights the need for a truly One Health response to this global problem. The 11th International Symposium on Avian Influenza aims to bring together scientists, biologists, veterinarians, medical researchers and professionals, and government regulators to exchange and discuss current scientific information on avian influenza and will address national and international issues focusing on domestic animals, wildlife, and human health. The scientific program committee will select timely topics and invited international experts from universities, government research laboratories, regulatory agencies, the veterinary biologics and poultry production industries, and other relevant organizations globally.